This paper introduces a new method of compressing digital images by using the Difference Console Exchanged Board Transform applied in medical imaging.The Difference Transform algorithm performs the decorrelation process of image data, and in this way improves the encoding process, achieving a file with a smaller size than the original.The proposed method proves to be competitive and in many cases better than the 4 Piece King Poster Bed standards used for medical images such as TIFF or PNG.In addition, the Difference Transform can replace other transforms like Cosine or Wavelet.